γ-H2AX foci/cell in human leukapheresis-derived mononuclear cells, stratified by disease subgroups which contribute to oxidative stress and/or DNA damage (with the exception of benign prostatic hyperplasia).

Average γ-H2AX foci/cell is shown for each disease subgroup and significance is adjusted for age and sex. Vitamin D deficient patients show an increase of 41% of γ-H2AX foci/cell compared to the cells from those without known vitamin D deficiency (p = 0.023). There is also a similar strong trend (30–39% increase in average number of γ-H2AX foci/cell, that does not quite reach significance; p values p = 0.23). Patients with cancer (Basal cell carcinoma or visceral cancer which includes prostate and colon cancer) showed no significant differences. Patients with benign prostatic hyperplasia also did not show any significant differences, as expected.*one patient had both a visceral cancer and a basal cell carcinoma.#adjusted for age.

本研究报告了各疾病亚组的平均每细胞γ-H2AX焦点(γ-H2AX foci)数量，且所有显著性检验结果均已针对年龄与性别进行校正。相较于无明确维生素D缺乏的受试者来源的细胞，维生素D缺乏患者的每细胞γ-H2AX焦点数量升高41%（p=0.023）。此外还观察到相似的显著趋势：每细胞γ-H2AX焦点平均数量升高30%~39%，但未达到统计学显著性水平（p=0.23）。癌症患者（涵盖基底细胞癌及内脏癌症，如前列腺癌与结肠癌）未呈现显著统计学差异。如预期所料，良性前列腺增生患者同样未出现显著统计学差异。*1名患者同时罹患内脏癌症与基底细胞癌。#该分析已针对年龄进行校正。