Thomson2009 – Unlimited multistability in multisite phosphorylation systems

This model describes a distributive, sequential system with n = 4, which is a simplified example of unlimited multistability in multisite phosphorylation systems. This method can be applied to systems with multiple substrates and enzymes.
This model is described in the article: Unlimited multistability in multisite phosphorylation systems. Thomson, Matthew & Gunawardena, Jeremy. (2009). Nature. 460. 274-7. 10.1038/nature08102 (https://www.nature.com/articles/nature08102).

Antimony and Tellurium used.

Figure 2 of the reference publication has been reproduced. The code files are available on Github (https://github.com/SunnyXu/Unlimited_multistability). The simulation was performed using Spyder for Tellurium 3.7 (http://tellurium.analogmachine.org/).

本模型构建了一个n=4的分布式顺序系统，其为多位点磷酸化系统中无限多稳态的简化范例。该方法可推广至包含多种底物与酶的各类系统。
本模型的相关内容刊载于下述学术论文：《多位点磷酸化系统中的无限多稳态》(Unlimited multistability in multisite phosphorylation systems)，作者为Matthew Thomson与Jeremy Gunawardena，发表于2009年《自然》(Nature)期刊第460卷，页码范围274-7，DOI：10.1038/nature08102，原文链接：https://www.nature.com/articles/nature08102。
本次研究使用了Antimony与Tellurium工具。本研究复现了该参考文献中的图2。代码文件可于GitHub(https://github.com/SunnyXu/Unlimited_multistability)获取。仿真工作基于适配Tellurium 3.7的Spyder环境完成，相关平台网址为http://tellurium.analogmachine.org/。