Novel biomarkers for a personalized managemnet of Type II Diabetes [islet]

Quantitative measurement of circulating metabolites may help to identify tissue specific metabolic pathways that are modulated by or causal for a disease condition. The aim of the study was to explore associations between plasma lipid concentrations and gene expression in pancreatic β-cells and insulin target tissues in a mouse model of pre-diabetes to uncover molecular mechanisms and biomarkers of diabetes susceptibility. Murine pancreatic islets transcriptome of three genetically different mouse strains (C57Bl/6, DBA/2J and BALB/cJ), fed with a high fat diet (HFD) or a regular chow (RC) for different periods of time: 5, 13 and 13 days.

循环代谢物的定量检测，有助于识别受疾病状态调控或与疾病存在因果关联的组织特异性代谢通路。本研究旨在通过前驱糖尿病小鼠模型，探究血浆脂质浓度与胰腺β细胞、胰岛素靶组织基因表达之间的关联，以揭示糖尿病易感性的分子机制与生物标志物。本数据集涵盖三种遗传背景各异的小鼠品系（C57Bl/6、DBA/2J与BALB/cJ）的胰岛转录组数据；这些小鼠分别以高脂饮食（high fat diet, HFD）或常规饲料（regular chow, RC）喂养，干预时长分别为5天、13天及13天。