Comparative study of transepidermal water loss in patients with and without hyperhidrosis by closed-chamber measurer in an air-conditioned environment

ABSTRACT Objective To evaluate the difference in transepidermal water loss in patients diagnosed with hyperhidrosis and healthy subjects, in an air-conditioned environment. Methods Twenty patients diagnosed with hyperhidrosis and 20 healthy subjects were subjected to quantitative assessment using a closed-chamber device, in six previously established sites. Results The measurements showed different transepidermal water loss values for healthy subjects and patients with hyperhidrosis, especially in the hands and feet. In the Control Group, the median for the hands was 46.4g/m2/hour (p25: 36.0; p75: 57.6), while in the Hyperhidrosis Group, the median was 123.5g/m2/hour (p25: 54.3; p75: 161.2) – p<0.001. For the feet, the Control Group had a median of 41.5g/m2/hour (p25: 31.3; p75: 63.5) and the Hyperhidrosis Group, 61.2g/m2/hour (p25: 32.3; p75: 117) – p<0.02. Measurements of the axillas also showed differences. In the Control Group, the median was 14.8g/m2/hour (p25: 11.8; p75: 19.0) and, in the Hyperhidrosis Group, 83.5g/m2/hour (p25: 29.5; p75: 161.7) – p<0.001. Conclusion Measuring transepidermal water loss is sufficient for diagnosis and follow-up of patients with hyperhidrosis.

摘要 研究目的：评估空调环境下多汗症患者与健康受试者的经皮水分丢失（transepidermal water loss）水平差异。方法：纳入20例确诊多汗症患者及20例健康受试者，采用密闭舱装置对6个预先设定的检测部位进行定量检测。结果：检测结果显示，健康受试者与多汗症患者的经皮水分丢失值存在显著差异，尤以手足部位最为突出。手部检测中，对照组中位数为46.4g/m²/小时（四分位间距p25:36.0；p75:57.6），多汗症组中位数为123.5g/m²/小时（p25:54.3；p75:161.2），组间差异具有统计学意义（p<0.001）。足部检测中，对照组中位数为41.5g/m²/小时（p25:31.3；p75:63.5），多汗症组为61.2g/m²/小时（p25:32.3；p75:117），组间差异具有统计学意义（p<0.02）。腋窝部位检测同样显示组间差异：对照组中位数为14.8g/m²/小时（p25:11.8；p75:19.0），多汗症组为83.5g/m²/小时（p25:29.5；p75:161.7），组间差异具有统计学意义（p<0.001）。结论：经皮水分丢失检测可有效用于多汗症患者的诊断及随访管理。