Evaluation of relationship between hematocrit and lipid profile in adults

ABSTRACT Introduction and objective: This study was carried out to analyze the relationship between hematocrit and lipid profile in adults. Material and method: A sample composed of complete blood counts and lipid profiles from the database of Hospital das Clínicas da Universidade de São Paulo (HCUSP), São Paulo, Brazil, was used in the analysis. Hematocrit was organized in five groups that were compared with total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), non-high-density-lipoprotein cholesterol (NHDL-C) and high-density-lipoprotein cholesterol (HDL-C) by means of chi-squared and Kruskal-Wallis tests. Results: Both tests showed a relevant correlation between hematocrit and lipid profile, considering a p-value < 0.05. Moreover, descriptive statistics revealed that the higher the hematocrit, the higher the proportion of people without recommended levels of each type of cholesterol, such TC, LDL-C, and NHDL-C. Just HDL-C showed an inverse association compared to the other variables, with an increased proportion of recommended levels along with rising of hematocrit. Conclusion: The relationship between hematocrit and lipid profile in all aspects of this study was more evident in women; nevertheless, the higher proportion of not recommended levels of HDL-C was shown in men. The reverse cholesterol transport probably plays an important role in the increase of cholesterol levels in blood in the presence of high hematocrit, by interaction of HDL-C and erythrocytes. Thus, further studies are necessary to elucidate these findings and to describe more aspects of the reverse cholesterol transport and its relationship with hematocrit and lipid profile.

摘要
引言与研究目的：本研究旨在分析成人血细胞比容（hematocrit）与血脂谱（lipid profile）之间的关联。
材料与方法：本分析采用巴西圣保罗市圣保罗大学临床医院（Hospital das Clínicas da Universidade de São Paulo, HCUSP）数据库中的全血细胞计数及血脂谱数据作为研究样本。将血细胞比容划分为5个组别，通过卡方检验（chi-squared test）与克鲁斯卡尔-沃利斯检验（Kruskal-Wallis test），分别与总胆固醇（total cholesterol, TC）、低密度脂蛋白胆固醇（low-density-lipoprotein cholesterol, LDL-C）、非高密度脂蛋白胆固醇（non-high-density-lipoprotein cholesterol, NHDL-C）及高密度脂蛋白胆固醇（high-density-lipoprotein cholesterol, HDL-C）进行比较。
结果：当p值<0.05时，两项检验均证实血细胞比容与血脂谱存在显著相关性。此外，描述性统计结果显示：血细胞比容越高，总胆固醇、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇未达推荐水平的人群比例越高；仅高密度脂蛋白胆固醇与其余指标呈反向关联，即随着血细胞比容升高，其推荐水平达标人群的比例随之升高。
结论：本研究中，血细胞比容与血脂谱的相关性在女性群体中更为显著，但男性群体中未达推荐水平的高密度脂蛋白胆固醇比例更高。反向胆固醇转运（reverse cholesterol transport）可能通过高密度脂蛋白胆固醇与红细胞的相互作用，在高血细胞比容状态下的血液胆固醇水平升高过程中发挥重要作用。因此，需开展进一步研究以阐明上述发现，并深入解析反向胆固醇转运的更多特征及其与血细胞比容和血脂谱的关联。