Changes in Gene Expression Profiles in Patients with Pulmonary Arterial Hypertension Associated with Scleroderma Treated with Tadalafil

The study looked at changes in gene expression profiles in subjects with Pulmonary Arterial Hypertension and Scleroderma (PAH-SSc) before and after treatment with Tadalafil. A total of ten subjects were enrolled and various clinical assessments including 6-minute walk tes, cardiac MRI and right heart catheterization were done in addition to gene expression study. An open label study with subjects who have pulmonary arterial hypertension and scleroderma treated with tadalafil and their gene expression profiles were analyzed before and after tadalafil treatment

本研究考察了肺动脉高压合并硬皮病（Pulmonary Arterial Hypertension and Scleroderma, PAH-SSc）患者接受他达拉非（Tadalafil）治疗前后的基因表达谱变化。研究共纳入10名受试者，除基因表达分析外，还完成了包括6分钟步行试验（6-minute walk test）、心脏磁共振成像（cardiac MRI）及右心导管术（right heart catheterization）在内的多项临床评估。本项研究为开放标签研究，对接受他达拉非治疗的肺动脉高压合并硬皮病患者的治疗前后基因表达谱进行了分析。