Comparison of WapCre;Rank;Brca1;p53 and WapCre;Brca1;p53 mouse primary mammary tumors. Mus musculus

The transcriptional profile of WapCre;Rank;Brca1;p53 and WapCre;Brca1;p53 mouse primary mammary tumor cells was determined by mRNA sequencing and uncovered differences in their molecular signatures including genes involved in oncogenesis, basic metabolism, RNA metabolism, or the regulation of mammary stem cells. Overall design: Transcriptome comparison of mouse WapCre;Rank;Brca1;p53 and WapCre;Brca1;p53 primary mammary tumors

本研究通过mRNA测序（mRNA sequencing）测定了WapCre;Rank;Brca1;p53与WapCre;Brca1;p53小鼠原代乳腺肿瘤细胞的转录组谱，揭示了二者分子特征的差异，相关差异基因涉及肿瘤发生、基础代谢、RNA代谢及乳腺干细胞调控等生物学过程。实验整体设计：对WapCre;Rank;Brca1;p53与WapCre;Brca1;p53小鼠原代乳腺肿瘤开展转录组比较分析。