Replication Data for: Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: a cross-sectional study

This research project builds on strong preliminary data that suggest environmental arsenic exposure induces degradation of the cystic fibrosis transmembrane regulator (CFTR), the chloride channel that is absent or defective in the genetic disease cystic fibrosis. Data from this epidemiological study investigates associations between environmental arsenic exposure, lung function, glucose tolerance, sweat chloride, and CFTR concentrations in peripheral mononuclear blood cells. These studies take place in Bangladesh, a country experiencing an unprecedented epidemic of arsenic poisoning through contaminated drinking water.

本研究依托坚实的前期研究数据展开，该数据表明环境砷暴露会诱导囊性纤维化跨膜传导调节因子（cystic fibrosis transmembrane regulator, CFTR）的降解——该氯离子通道在囊性纤维化这一遗传性疾病中存在缺失或功能缺陷。本项流行病学研究的数据旨在探究环境砷暴露与肺功能、糖耐量、汗液氯离子浓度以及外周血单核细胞中CFTR浓度之间的关联。本研究的开展地点为孟加拉国，该国正因受污染的饮用水经历一场前所未有的砷中毒流行疫情。