Crystal structure of human Fgr tyrosine kinase in complex with A-419259

Crystal structure of human Fgr tyrosine kinase in complex with A-419259 Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... Authors: Du, S, Alvarado, J.J, Smithgall, T.E. Deposit date: 2022-05-06 Release date: 2022-12-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.55 Å) Cite: ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022人源Fgr酪氨酸激酶（tyrosine kinase）与A-419259复合物的晶体结构 描述配体：7-[反式-4-(4-甲基哌嗪-1-基)环己基]-5-(4-苯氧基苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺、氯离子、甘油等 作者：Du, S、Alvarado, J.J、Smithgall, T.E. 提交日期：2022-05-06 发布日期：2022-12-28 最后修改日期：2024-11-13 实验方法：X射线衍射（X-RAY DIFFRACTION）（分辨率2.55埃） 引用文献：ATP位点抑制剂（ATP-site inhibitors）可诱导与急性髓系白血病相关的Src家族激酶（Src-family kinase）Fgr产生独特构象。《Structure》，第30卷，2022年