<b>Exploring the correlation between homocysteine, </b><b>R</b><b>ed blood cell folate, and MTHFRC677T genotypes with female</b><b> </b><b>infertility</b>

<b>Abstract</b><b>Aim:</b><b> </b>To investigate the association between serum homocysteine (HCY) levels, red blood cell folate (RCF) levels, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism, and infertility. <b>Materials &amp; met</b><b>h</b><b>ods:</b><b> </b>Serum HCY and RCF levels and C677T polymorphism of MTHFR gene were analyzed in 149 infertile patients and 223 women of normal reproductive age with healthy childbirth history. <b>Results</b><b>: </b>The HCY level of MTHFR C677T TT genotype infertility patients was higher than that of women of normal reproductive age, while the RCF level was not significantly different between the two groups. <b>Conclusion:</b> Serum HCY levels increased in infertility patients, and the MTHFR C677T TT genotype in childbearing-aged women are associated with a higher risk of infertility.The results showed that HCY level and MTHFR C677T genotype were closely related to infertility .**摘要** **研究目的：** 探讨血清同型半胱氨酸（homocysteine, HCY）水平、红细胞叶酸（red blood cell folate, RCF）水平、亚甲基四氢叶酸还原酶（methylenetetrahydrofolate reductase, MTHFR）基因多态性与不孕症的关联。 **材料与方法：** 纳入149例不孕症患者与223例有健康生育史的正常育龄女性，检测其血清HCY、RCF水平及MTHFR基因C677T多态性。 **结果：** 携带MTHFR C677T TT基因型的不孕症患者血清HCY水平高于正常育龄女性，两组间RCF水平无显著差异。 **结论：** 不孕症患者血清HCY水平升高，育龄女性携带MTHFR C677T TT基因型与不孕症风险升高相关。本研究结果显示，血清HCY水平及MTHFR C677T基因型与不孕症密切相关。