Microbiome profiling of gut and skin in atopic dermatitis patients treated with WMT

This BioProject investigates the clinical effects and microbiome-modulating potential of washed microbiota transplantation (WMT) in patients with moderate-to-severe atopic dermatitis (AD). A total of 23 AD patients were enrolled and treated with WMT. Fecal and skin samples were collected before and after treatment to assess changes in microbial composition and diversity. The 16S rRNA gene sequencing was used to analyze the gut and skin microbiota. The aim of this study is to evaluate the gut-skin microbial axis in AD and to explore the potential therapeutic value of WMT in restoring microbiome balance and improving clinical symptoms.

本生物项目（BioProject）旨在探究洗涤菌群移植（washed microbiota transplantation, WMT）对中重度特应性皮炎（atopic dermatitis, AD）患者的临床疗效及其调控微生物组的潜力。本研究共纳入23名AD患者并予以WMT治疗。分别于治疗前后采集粪便与皮肤样本，以评估微生物组成与多样性的变化。研究采用16S rRNA基因测序技术分析肠道与皮肤微生物组。本研究旨在评估AD患者的肠-皮肤微生物轴，并探索WMT在恢复微生物组平衡、改善临床症状方面的潜在治疗价值。