9c58f453-6aea-4fb9-bcb2-3c46a867a576 - samples

We profiled 87 primary-recurrentpatient-matched paired GBM specimens with single-nucleus RNA and bulk-DNA sequencing and single-cell open-chromatin and spatial transcriptomics/proteomics assays. We found that recurrent GBMs are characterized by a shift to a mesenchymal phenotype in response to therapyEGA dataset EGAD00001008811

本研究对87例原发性-复发性患者匹配配对的胶质母细胞瘤（GBM）标本开展了多组学特征解析，所采用的技术涵盖单细胞核RNA测序、批量DNA测序、单细胞染色质开放测序以及空间转录组学/蛋白质组学检测。分析结果显示，复发性胶质母细胞瘤在接受治疗后呈现向间充质表型转化的特征。本数据集隶属于EGA数据库，编号为EGAD00001008811。