SOX2 Reprograms the Esophageal Squamous Carcinoma Epigenome and Induces Endogenous Retroviral Elements and dsRNA, Thereby Promoting ADAR1 Dependence [RNA-Seq]

We analyzed ChIP-seq, chromatin accessibility and RNA-seq across mouse esophageal squamous organoids and human esophageal squamous cell cancer Overall design: RNAseq analysis of esophageal squamous organoids and cancer cell lines

本研究在小鼠食管鳞状上皮类器官（mouse esophageal squamous organoids）及人类食管鳞状细胞癌样本中，开展了染色质免疫共沉淀测序（ChIP-seq）、染色质可及性分析与RNA测序（RNA-seq）相关分析。整体实验设计：针对食管鳞状上皮类器官与癌细胞系实施RNA测序分析。