Linker-Directed Assembly of Twisted ortho-Phenylene-Based Macrocycles

o-Phenylene tetramers have been coassembled with linkers into macrocycles through imine condensation. Variation of linker connectivity and length allows both [1 + 1] and [2 + 2] macrocycles to be obtained, complementing (previously reported) [3 + 3] macrocycles. For the [1 + 1] macrocycles, linker length has a clear effect on o-phenylene geometry and macrocycle stability. For the [2 + 2] macrocycles, both homo- and heterochiral configurations are observed, suggesting limited communication of helix handedness in these systems.邻亚苯四聚体（o-Phenylene tetramers）与连接体通过亚胺缩合反应共组装为大环化合物。通过调控连接体的连接模式与长度，可得到[1+1]型与[2+2]型大环，与此前报道的[3+3]型大环形成互补。对于[1+1]型大环，连接体长度对邻亚苯的几何构型及大环稳定性具有显著影响。对于[2+2]型大环，可同时观测到同手性与异手性两种构型，表明该体系内螺旋手性的传递作用有限。