GENOMIC CHARACTERIZATION OF EXTENSIVELY DRUG-RESISTANT (XDR) SALMONELLA TYPHI CLINICAL ISOLATES FROM TYPHOID ENDEMIC REGION OF PESHAWAR, PAKISTAN. Salmonella enterica subsp. enterica serovar Typhi

1. To characterize the genomic insights of locally prevalent extensively drug resistance (XDR) strains.To understand the antimicrobial resistance (AMR) pattern from whole genome sequences data of locally spread XDR Salmonella Typhi strains. To perform the phylogenetic and population structure inferences of local isolates in contextof global samples.

1. 解析本地流行的广泛耐药（extensively drug resistance, XDR）菌株的基因组学特征；基于本地传播的XDR伤寒沙门氏菌（Salmonella Typhi）菌株的全基因组序列数据，阐明其抗菌耐药（antimicrobial resistance, AMR）模式；结合全球样本的研究背景，开展本地分离株的系统发育与群体结构推断分析。