Puniya2021 - Naive CD4+ T cell metabolic model

CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response.
Naive CD4+ T cells are precursor cells that can differentiate into T helper - 1, - 2, - 17 (Th1, Th2, Th17) and regulatory T cells (Tregs) subtypes based on the type of pathogens or disease. The naive CD4+ T cell model consists of 5179 reactions, 3153 metabolites, and 1055 genes. Together with Th1, Th2, and Th17 models, the naive CD4+ T cell model helped identify drug targets and repurposable drugs against autoimmune diseases.

CD4+ T细胞（CD4+ T cells）是人体免疫系统的关键组成成分。该类细胞可分泌细胞因子以对抗病原体与异常细胞，并激活B细胞、巨噬细胞、中性粒细胞等其他免疫细胞，进而触发免疫应答。
初始CD4+ T细胞（Naive CD4+ T cells）作为一类前体细胞，可根据病原体或疾病的类型，分化为辅助性T细胞1型、辅助性T细胞2型、辅助性T细胞17型（T helper 1, T helper 2, T helper 17，简称Th1、Th2、Th17）以及调节性T细胞（regulatory T cells，简称Tregs）等亚型。该初始CD4+ T细胞模型包含5179个反应、3153种代谢物以及1055个基因。将该初始CD4+ T细胞模型与Th1、Th2及Th17模型联合使用时，可助力识别针对自身免疫性疾病的药物靶点与可重定位药物（repurposable drugs）。