Genetic vs Dietary Models of Iron Overload in the Mouse Liver. Mus musculus

Iron overload causes the generation of reactive oxygen species, which can lead to lasting damage to the liver and other organs. We studied the effects of iron deficiency and iron overload on the hepatic transcriptional and metabolomic profile in mouse models. Overall design: We studied effect of different iron overloads (High, medium and Low) on liver transcriptome using whole genome transcriptome profiling.

铁过载会诱生活性氧簇（reactive oxygen species）的生成，可对肝脏及其他器官造成永久性损伤。本研究以小鼠模型为对象，探究铁缺乏与铁过载对肝脏转录组及代谢组学特征的影响。实验设计概述：本研究采用全基因组转录组分析（whole genome transcriptome profiling）技术，探究不同程度（高、中、低）铁过载对小鼠肝脏转录组的影响。