Table_7_Identification of Risk Factors for Stroke in China: A Meta-Analysis of Prospective Cohort Studies.DOC

This study aimed to identify independent risk factors for first occurrence of stroke in Chinese individuals based on prospective cohort studies. Forty prospective cohort studies assessing 1,984,552 individuals were selected for the final meta-analysis. The identified risk factors for stroke in the Chinese population included old age (RR = 1.86, 95%CI: 1.47–2.36), hypertension (RR = 2.76, 95%CI: 2.26–3.37), cardiovascular disease history (RR = 1.98, 95%CI: 1.06–3.69), chronic kidney disease (RR = 1.65, 95%CI: 1.36–2.01), diabetes mellitus (RR = 1.71, 95%CI: 1.34–2.18), metabolic syndrome (RR = 1.59, 95%CI: 1.33–1.90), hyperglycemia (RR = 1.49, 95% CI: 1.31–1.69), obesity (RR = 1.45, 95%CI: 1.29–1.63), smoking (RR = 1.42, 95% CI: 1.27–1.58), prolonged sleep time (> 7.5 h, RR = 1.44, 95%CI: 1.19–1.75), higher levels of triglyceride (RR = 1.19, 95%CI: 1.07-1.32), C-reactive protein (RR = 1.34, 95%CI: 1.07-1.69). High fruit-rich diet (RR = 0.68, 95%CI: 0.58-0.80) was associated with a lower risk of stroke. The spectrum and power of risk factors varied among different cohort inclusion years. These findings provide a comprehensive tool for the primary prevention of stroke in Chinese individuals.

本研究旨在基于前瞻性队列研究（prospective cohort study），明确中国人群首次脑卒中（stroke）发生的独立危险因素。最终共纳入40项针对1984552名个体的前瞻性队列研究以进行最终荟萃分析（meta-analysis）。本研究鉴定出的中国人群脑卒中危险因素包括：高龄（相对危险度（Relative Risk, RR）=1.86，95%置信区间（95% Confidence Interval, 95%CI）：1.47~2.36）、高血压（hypertension，RR=2.76，95%CI：2.26~3.37）、心血管病史（cardiovascular disease history，RR=1.98，95%CI：1.06~3.69）、慢性肾脏病（chronic kidney disease，RR=1.65，95%CI：1.36~2.01）、糖尿病（Diabetes Mellitus，RR=1.71，95%CI：1.34~2.18）、代谢综合征（metabolic syndrome，RR=1.59，95%CI：1.33~1.90）、高血糖（hyperglycemia，RR=1.49，95%CI：1.31~1.69）、肥胖（obesity，RR=1.45，95%CI：1.29~1.63）、吸烟（smoking，RR=1.42，95%CI：1.27~1.58）、睡眠时间延长（每日＞7.5小时，RR=1.44，95%CI：1.19~1.75）、较高甘油三酯（triglyceride）水平（RR=1.19，95%CI：1.07~1.32）以及C反应蛋白（C-reactive protein）水平升高（RR=1.34，95%CI：1.07~1.69）。而高水果膳食模式（high fruit-rich diet，RR=0.68，95%CI：0.58~0.80）与脑卒中发病风险降低相关。不同队列纳入年份对应的危险因素谱及效应强度存在差异。本研究结果可为中国人群脑卒中的一级预防提供全面的参考工具。