Recombinant human butyrylcholinesterase in complex with 2-(cyclohexylmethyl)-5-(2,4-difluorophenoxy)-N-(2-(3-(methoxymethyl)piperidin-1-yl)ethyl)-2H-indazole-6-carboxamide

Recombinant human butyrylcholinesterase in complex with 2-(cyclohexylmethyl)-5-(2,4-difluorophenoxy)-N-(2-(3-(methoxymethyl)piperidin-1-yl)ethyl)-2H-indazole-6-carboxamide Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Brazzolotto, X, Ferjancic Benetik, S, Knez, D, Proj, M, Gobec, S, Nachon, F. Deposit date: 2025-01-28 Release date: 2025-08-20 Last modified: 2025-09-10 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38 alpha Mitogen-Activated Protein Kinase Inhibitors. J.Med.Chem., 68, 2025

与2-(环己基甲基)-5-(2,4-二氟苯氧基)-N-(2-(3-(甲氧基甲基)哌啶-1-基)乙基)-2H-吲唑-6-甲酰胺结合的重组人丁酰胆碱酯酶（butyrylcholinesterase）。
描述项：2-(N-吗啉代)乙磺酸（2-(N-MORPHOLINO)-ETHANESULFONIC ACID）、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-岩藻吡喃糖（alpha-L-fucopyranose）-(1→6)]-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖……
作者：Brazzolotto, X、Ferjancic Benetik, S、Knez, D、Proj, M、Gobec, S、Nachon, F
提交日期：2025-01-28；发布日期：2025-08-20；最后修改日期：2025-09-10
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.36埃（Å）
引用文献：《靶向神经炎症与认知衰退：首款兼具丁酰胆碱酯酶与p38α丝裂原活化蛋白激酶（Mitogen-Activated Protein Kinase）双重抑制活性的首创类化合物》，《药物化学杂志》（J.Med.Chem.），68卷，2025年