Nucleotide and amino acid sequence comparison of the moose HEV genome to other HEV genomes.

The moose HEV ORF1 with some internally selected domains: methyltransferase, Y-domain, PCP and HVR were compared to other HEVs. Subsequent analyses of the helicase and RdRp of ORF1, 1968 nt ORF2 and 348 nt ORF3 were presented in a previous study [28].*Compared hepevirus sequences obtained from Genbank, gt1:AY204877; gt2:M74506; gt3:AB222182, AF082843, AB591734, EU360977 and FJ906895; gt4:AY594199, GU119961 and AB521806; gt5:AB573435; gt6:AB602441; Rat HEV: GU345042; Ferret HEV: JN998606; Bat HEV: JQ001749; Avian HEV: AM943646; Fish HEV: HQ731015.Nucleotide and amino acid sequence comparison of the moose HEV genome to other HEV genomes.

将带有内部筛选获得的结构域（含甲基转移酶、Y结构域、PCP及高变区（HVR））的驼鹿戊型肝炎病毒（Hepatitis E virus, HEV）开放阅读框1（Open Reading Frame 1, ORF1）序列与其他戊型肝炎病毒序列进行比对。针对ORF1的解旋酶与RNA依赖的RNA聚合酶（RNA-dependent RNA polymerase, RdRp）、长度为1968 nt的开放阅读框2（Open Reading Frame 2, ORF2）以及348 nt的开放阅读框3（Open Reading Frame 3, ORF3）的后续分析，已在既往研究[28]中发表。*本次比对所采用的戊型肝炎病毒科（Hepeviridae）序列均源自GenBank数据库，具体信息如下：基因型1型（gt1）：AY204877；基因型2型（gt2）：M74506；基因型3型（gt3）：AB222182、AF082843、AB591734、EU360977及FJ906895；基因型4型（gt4）：AY594199、GU119961及AB521806；基因型5型（gt5）：AB573435；基因型6型（gt6）：AB602441；大鼠戊型肝炎病毒：GU345042；雪貂戊型肝炎病毒：JN998606；蝙蝠戊型肝炎病毒：JQ001749；禽戊型肝炎病毒：AM943646；鱼类戊型肝炎病毒：HQ731015。本研究同时完成了驼鹿戊型肝炎病毒基因组与其他戊型肝炎病毒基因组的核苷酸及氨基酸序列比对分析。