Genetic dysregulation of gene expression and splicing during a ten-year period of human aging in the PIVUS study

We performed RNA sequencing in whole-blood from the same individuals from the PIVUS study at ages 70 and 80 to quantify how gene expression, alternative splicing, and their genetic regulation are altered during this 10-year period of advanced aging.EGA study EGAS00001003583我们针对PIVUS研究中的同一批受试者，分别于70岁和80岁时采集其全血样本开展RNA测序（RNA sequencing），以量化这10年高龄衰老周期内，基因表达、可变剪接（alternative splicing）及其遗传调控所发生的变化。本数据集关联EGA研究（EGA study）编号EGAS00001003583。