Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx

Objective:To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx.Methods: We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk in different populations worldwide.Results: We initially found 65 articles and, after selection criteria, 20 case-control studies with various populations worldwide were eligible. The most studied polymorphisms were those of CYP2E1 and CYP1A1 subfamilies. There is little about the other subfamilies. The association found between polymorphisms and cancer risk amounted to a countless number of variables, amongst them: population, selection methods, racial factors and different modes of exposure to carcinogens, genotyping methods, and nomenclature of the polymorphisms.Conclusion: so far, there is no proven link between genetic polymorphisms of cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx relationship.

研究目的：分析细胞色素P450（cytochrome P450）家族基因多态性及其与口腔、咽及喉鳞状细胞癌的关联。研究方法：本研究采用叙述性文献综述方法，检索了近五年发表于PubMed、LILACS及Cochrane数据库的相关文献，探讨全球不同人群中细胞色素P450家族基因多态性与癌症风险的关联。研究结果：初步检索共获得65篇文献，经筛选标准纳入后，最终有20项针对全球不同人群的病例对照研究符合纳入标准。其中研究最为广泛的为CYP2E1及CYP1A1亚家族的基因多态性，其余亚家族的相关研究则较为匮乏。现有研究显示，基因多态性与癌症风险之间的关联受诸多变量影响，包括人群特征、研究对象筛选方法、种族因素、致癌物暴露的不同途径、基因分型方法以及多态性的命名体系等。研究结论：截至目前，尚无确凿证据证实细胞色素P450家族基因多态性与口腔、咽及喉鳞状细胞癌之间存在明确关联。