Genome-scale chromatin interaction data for huntingtin from mouse striatal tissue. Mus musculus

Transcriptional changes are an early feature of Huntington's disease (HD). We profiled genome-wide interaction sites for the huntingtin protein (HTT) using ChIP-sequencing from mouse striatal tissue at 4 months of age. We include replicate samples from CAG-expanded murine Htt (heterozygous Q111/+) and wildtype littermate controls. Overall design: ChIP-seq for HTT (huntingtin) in wild type and Q111/+ CAG-expanded knock-in mouse striatum at 4 months of age.

转录水平的改变是亨廷顿舞蹈症（Huntington's disease, HD）的早期典型特征。本研究采用染色质免疫共沉淀测序（ChIP-sequencing）技术，对4月龄小鼠纹状体组织内的亨廷顿蛋白（huntingtin protein, HTT）全基因组结合位点进行了图谱绘制。本研究纳入了CAG扩增型小鼠Htt基因杂合突变（Q111/+）及其野生型同窝对照的重复样本。实验整体设计：对4月龄野生型与CAG扩增型敲入小鼠的纹状体组织开展HTT（亨廷顿蛋白）的染色质免疫共沉淀测序实验。