Supplementary Material for: Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism

<i>Objective:</i> To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism. <i>Methods:</i> We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features. <i>Results</i>: All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance. Clinical features of 18 of the 23 patients were compatible with progressive supranuclear palsy (PSP); 2 patients were compatible with parkinsonian type multiple system atrophy; 2 patients were compatible with mixed clinical features of both; and 1 patient had PSP-like clinical features. <i>Conclusions:</i> Most parkinsonian patients with SCS present rapidly progressive parkinsonism predominated by postural instability and gait disturbance. SCS observed in patients with parkinsonism does not seem to be a coincidental finding associated with the generalized cerebrovascular process.

**研究目的**：明确原发性进行性帕金森综合征（primary progressive parkinsonism）患者中观察到的纹状体筛状状态（striatal cribriform state, SCS）的临床意义。
**研究方法**：本研究回顾性分析了1260例原发性进行性帕金森综合征患者的病历资料与颅脑磁共振成像（magnetic resonance imaging, MRI）检查结果，最终确认23例存在SCS的患者，并对其临床特征展开分析。
**研究结果**：23例患者均表现为以姿势不稳与步态障碍为主要表现的快速进展型帕金森综合征。其中18例患者的临床特征符合进行性核上性麻痹（progressive supranuclear palsy, PSP）；2例符合帕金森亚型多系统萎缩（parkinsonian type multiple system atrophy）；2例兼具二者的混合临床特征；1例表现为类进行性核上性麻痹临床特征。
**研究结论**：多数伴SCS的帕金森综合征患者会出现以姿势不稳与步态障碍为核心特征的快速进展型帕金森综合征。帕金森综合征患者中观察到的SCS，似乎并非与广泛性脑血管病变相关的偶然发现。