Fragility fractures might be predicted by the overall cardiovascular burden in endogenous Cushing syndrome

Endogenous CS represents a complex condition associated with a negative impact on long-term mortality and morbidity. Among the various complications, cardiovascular and skeletal issues stand out as particularly debilitating . However, these intriguing findings indicate the overall burden of cardiovascular morbidity as potential novel shared predictors of damage affecting the bone-vascular axis, and impacting the risk of fracture, extending beyond the mere degree of cortisol excess. The present study is the first that offers a holistic assessment of the interplay between fracture risk, bone quality, and cardiovascular morbidity in overt endogenous CS.

内源性库欣综合征（Endogenous Cushing Syndrome, CS）是一类复杂病症，与长期死亡率及发病率升高存在显著相关性。在其各类并发症中，心血管与骨骼系统病变尤为突出，可导致患者出现严重的机能衰弱。然而，上述颇具研究价值的发现表明，心血管疾病的整体负担可作为潜在的新型共通预测因子，用于预判影响骨-血管轴的损伤，并提升骨折风险——其关联效应远超单纯的皮质醇过量水平。本研究为首项针对显性内源性库欣综合征患者，全面评估骨折风险、骨质量与心血管疾病发病率之间相互作用的研究。