Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17

Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17 Descriptor: (2~{E})-5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one, Acetylcholinesterase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Caliandro, R, Pesaresi, A, Lamba, D. Deposit date: 2017-02-28 Release date: 2018-05-02 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. J Enzyme Inhib Med Chem, 33, 2018

加州电鳐 (Torpedo californica) 乙酰胆碱酯酶 (Acetylcholinesterase) 与非手性多奈哌齐类抑制剂17形成的复合物。描述符：(2E)-5,6-二甲氧基-2-[[1-(苯甲基)哌啶-4-基]亚甲基]-3H-茚-1-酮、乙酰胆碱酯酶、α-D-吡喃甘露糖-(1→3)-β-D-吡喃甘露糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖……。作者：Caliandro R、Pesaresi A、Lamba D。提交日期：2017-02-28；发布日期：2018-05-02；最后修改日期：2024-10-23。实验方法：X射线衍射 (X-RAY DIFFRACTION)，分辨率2.17 Å。引用文献：《加州电鳐乙酰胆碱酯酶与两种多奈哌齐类刚性类似物的相互作用动力学及结构研究》，《酶抑制与药物化学杂志》(J Enzyme Inhib Med Chem)，2018年，第33卷。