MT1-MMP induces malignant transformation in Mammary cells

Expression of the MT1-MMP gene induces a significant upregulation of of oncogenes and tumorignenic genes in 184B5-MT1 cells. Keywords: Genetic modification Three biological replicates of untransfected Mammary cell line compared to MT1-MMP transfected Mammary cell line. Singel channel data from the illumina platform. After normalisation and t-tests differential gene expression was determined between the two groups using p-values and fold change.MT1-MMP基因的表达可在184B5-MT1细胞中诱导癌基因与致瘤基因的显著上调。 关键词：基因修饰（Genetic modification） 本数据集以三组未转染乳腺细胞系的生物学重复样本为对照，与转染MT1-MMP的乳腺细胞系的三组生物学重复样本进行对比，数据来源于Illumina（illumina）平台的单通道测序数据。经过标准化处理与t检验后，本研究通过p值与倍数变化（fold change）确定了两组间的差异基因表达情况。