Resolving the mesoscopic missing link: biophysical modeling of EEG from cortical columns in primates

Event-related potentials (ERP) are among the most widely measured indices for studying human cognition. While their timing and magnitude provide valuable insights, their usefulness is limited by our understanding of their neural generators at the circuit level. Inverse source localization offers insights into such generators, but their solutions are not unique. To address this problem, scientists have assumed the source space generating such signals comprises a set of discrete equivalent current dipoles, representing the activity of small cortical regions. Based on this notion, theoretical studies have employed forward modeling of scalp potentials to understand how changes in circuit-level dynamics translate into macroscopic ERPs. However, experimental validation is lacking because it requires in vivo measurements of intracranial brain sources. Laminar local field potentials (LFP) offer a mechanism for estimating intracranial current sources. Yet, a theoretical link between LFPs and int...

事件相关电位（Event-related potentials, ERP）是研究人类认知的最常用检测指标之一。尽管其时间进程与振幅大小能够提供极具价值的研究视角，但该技术的应用价值受限于我们对其在神经环路层面的神经发生器的认知。逆源定位（Inverse source localization）可用于解析这类神经发生器，但其求解结果并不唯一。为解决这一难题，科研人员假设生成此类信号的源空间由一组离散的等效电流偶极子（equivalent current dipoles）构成，以此表征小型皮层脑区的神经活动。基于这一假设，理论研究通过头皮电位正向建模，探究神经环路层面的动态变化如何转化为宏观事件相关电位。然而此类研究缺乏实验验证，因为其需要获取颅内脑源的在体测量数据。层状局部场电位（Laminar local field potentials, LFP）为颅内电流源的估算提供了可行途径。然而，层状局部场电位与颅内……