Small cell lung cancer (SCLC) is highly invasive and lethal. Here we performed RNA-Seq and whoe exome sequencing (WES) in 19 Chinese SCLC clinical tumor specimens.. Multi-omics data reveals the heterogeneity for Chinese small cell lung cancer

Small cell lung cancer (SCLC) is highly invasive and lethal. Genomic studies are beginning to characterize its genetic determinants and heterogeneity. Here we performed RNA-Seq and whoe exome sequencing (WES) in 19 Chinese SCLC clinical tumor specimens. Integration with other two public cohorts (n=129 for RNA-seq, n=171 for WES), we carried out gene co-expression network analysis and classified into four subgroups.

小细胞肺癌（Small cell lung cancer, SCLC）具有极高的侵袭性与致死性。当前基因组学研究正逐步阐明其遗传决定因素与肿瘤异质性。本研究在19例中国小细胞肺癌临床肿瘤标本中开展了RNA测序（RNA-Seq）与全外显子组测序（whole exome sequencing, WES）。结合另外两公共队列（RNA测序队列样本量n=129，全外显子组测序队列样本量n=171），我们开展了基因共表达网络分析，并将样本划分为四个亚组。