Additional file 2: of Synchronous birth is a dominant pattern in receptor-ligand evolution

Part 1: List of Databases used to construct the receptor/ligand interaction Database. Part 2: Characteristics of the components of the MCA. Part 3: Explanation of the statistical model. Part 4 Organisms of the branches of the overall phylogenetic trees + organisms implemented by BLAST. Part 5: Supplementary discussion on the appearance times of ligands and receptors. Part 6: Results of the random statistical model for the different combinations used. Part 7: Explanation of the methodology to match the bases Ensembl and Ensembl metazoa. Part 8: Number of receptors according to their number of ligands. Part 9: List of ligands and receptors in our database. (ODT 46 kb)

第一部分：用于构建受体-配体相互作用数据库的数据库列表。第二部分：MCA的组分特征。第三部分：统计模型说明。第四部分：整体系统发育树各分支涉及的物种，以及BLAST所应用的物种。第五部分：关于配体与受体出现时间的补充讨论。第六部分：所用不同组合的随机统计模型结果。第七部分：匹配Ensembl与Ensembl metazoa数据库的方法说明。第八部分：按配体数目分类的受体数量统计。第九部分：本数据库中的配体与受体列表（ODT 46 kb）