DEMETER 2 Combined RNAi

Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to the combination of three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. This dataset is derived from https://doi.org/10.6084/m9.figshare.6025238.v4 and formatted to more closely match quarterly releases. Specifically, the main matrices have been transposed so that they are indexed by cell line, cell lines are identified by DepMap IDs, and common dependencies and dependency probability estimated. Only select files are included. Refer to the original dataset for all files. See README for more information about files.<br>Visit the Cancer Dependency Map portal at https://depmap.org to explore related datasets. Email questions to [e-mail]<br>

基于DEMETER2模型估算的癌细胞系遗传依赖关系数据集。该模型被应用于整合三大规模RNA干扰（RNAi）筛选数据集：布罗德研究所的Achilles项目、诺华制药的DRIVE项目，以及Marcotte等团队发布的乳腺细胞系数据集。本数据集源自https://doi.org/10.6084/m9.figshare.6025238.v4，并调整格式以更贴合季度更新版本的规范。具体而言，主矩阵已完成转置，以癌细胞系作为索引；癌细胞系通过DepMap标识符进行标识，并估算得到通用遗传依赖关系及依赖概率值。本数据集仅包含部分筛选后的文件，完整文件列表请参阅原始数据集。有关文件的详细信息，请参阅README文件。<br>请访问https://depmap.org的癌症依赖图谱门户以探索相关数据集，如有疑问请发送邮件至[e-mail]。