Nutritional characteristics of patients with Huntington disease according to sex, compared to controls.

The values represent the mean±standard deviations. Ranges are in parentheses. The HD group was compared to controls (ANOVA).ADetermined retrospectively for a 5-year period.BDetermined by bioelectric impedance.CDetermined from a 3-day and a 24-hour questionnaire performed at a one-month interval. Weight loss was significant in the HD group, in both men and women. Despite significantly higher calories intake, carriers of huntingin mutations did not have a higher BMI (body mass index). In men, BMI and lean body mass were lower in the HD group despite higher food intake. These nutritional analyses demonstrate the existence of a hypermetabolic state in the early stages of HD.

所有数值均以平均值±标准差形式呈现，取值范围标注于括号内。本研究采用方差分析（ANOVA）对亨廷顿病（Huntington's disease, HD）组与对照组进行比较。注：A. 基于5年周期的回顾性研究确定；B. 通过生物电阻抗分析法测定；C. 基于间隔1个月开展的3天及24小时膳食问卷结果确定。亨廷顿病组无论男性还是女性均出现显著体重下降。尽管卡路里摄入量显著更高，但亨廷顿基因突变携带者的体重指数并未更高。在男性群体中，尽管食物摄入量更高，但亨廷顿病组的体重指数与瘦体重均更低。本项营养分析证实，亨廷顿病早期阶段存在高代谢状态。