Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats

The present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventricular block incidence following the ischemia and reperfusion procedure. In addition, significant alterations were observed in electrocardiogram intervals during the stabilization, ischemia, and reperfusion periods of rats with epilepsy compared to control rats. It was noted that rats with epilepsy presented a significant increase in the QRS interval during the stabilization period in relation to control rats (P

本研究针对癫痫大鼠，采用心脏缺血再灌注诱导的急性心肌梗死（AMI）模型，评估其心电图变化。将大鼠随机分为两组：对照组（n=12）与癫痫组（n=14）。研究发现，癫痫大鼠在缺血再灌注术后的房室传导阻滞发生率显著降低。此外，与对照组大鼠相比，癫痫大鼠在稳定期、缺血期及再灌注期的心电图间期均出现显著变化。研究同时观察到，与对照组相比，癫痫大鼠在稳定期的QRS间期显著延长（P