Additional file 2: of The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Figure S1. Flow diagram of patients enrollment. PJS indicates Peutz-Jeghers syndrome. Figue S2. The predicted protein structure of 8 truncating mutations (A) and the PolyPhen-2 prediction results for 5 missense mutations (B). NLS, nuclear location signal. Figure S3. Western blot results of the mutation investigated. Targeted protein: STK11; internal reference: GAPDH. (ZIP 2634 kb)

图S1 患者入组流程图。PJS即色素沉着息肉综合征（Peutz-Jeghers syndrome）。图S2：8种截短突变的预测蛋白结构（A）与5种错义突变的PolyPhen-2预测结果（B）。NLS即核定位信号（nuclear location signal）。图S3 所研究突变的蛋白质免疫印迹（Western blot）实验结果：靶蛋白为STK11，内参为GAPDH。（ZIP 2634 kb）