Data Sheet 2_Association of plasma homocysteine with cardiovascular disease in American adults: a study based on the national health and nutrition examination survey database.csv

ObjectiveThe purpose of this study was to investigate the correlation between plasma homocysteine (Hcy) levels and cardiovascular disease (CVD) in United States adults based on the National Health and Examination Survey (NHANES) database of the United States.
MethodsData from two survey periods (2003–2006) in the NHANES database were used as the research data set. Plasma Hcy levels are considered an independent variable, while CVD is a dependent variable. Weighted logistic regression, linear trend analysis, subgroup analysis and limiting cubic spline plots were used for analysis. A total of 4,418 samples were included.
ResultsIn the weighted logistic regression model, a significant positive correlation between Hcy level and CVD risk was observed (P for trend = 0.007).The subgroup analysis revealed that various characteristics such as age, race, education level, obesity, alcohol use, diabetes, and hypertension did not affect this positive correlation (P for interaction ≥0.05). The nonlinear association between Hcy level and CVD risk was explored by limiting cubic spline plots, revealing the overall significant trend (P for overall <0.0001) and the significant nonlinear trend (P for nonlinear <0.01).
ConclusionIn this large cross-sectional study, an increase in Hcy levels leads to an increased risk of CVD. There is a nonlinearly positive correlation between Hcy levels and the risk of CVD.

研究目的：本研究旨在基于美国国家健康与营养检查调查（National Health and Examination Survey, NHANES）数据库，探讨美国成人血浆同型半胱氨酸（plasma homocysteine, Hcy）水平与心血管疾病（cardiovascular disease, CVD）之间的相关性。
研究方法：本研究采用NHANES数据库中2003–2006年两个调查周期的数据作为研究数据集。以血浆同型半胱氨酸水平作为自变量，心血管疾病为因变量。分析采用加权Logistic回归、线性趋势分析、亚组分析以及限制性立方样条图法，最终纳入样本共计4418例。
研究结果：在加权Logistic回归模型中，观察到血浆同型半胱氨酸水平与心血管疾病风险存在显著正相关关系（趋势检验P=0.007）。亚组分析显示，年龄、种族、受教育程度、肥胖、饮酒情况、糖尿病及高血压等各项特征均未对该正相关关系产生影响（交互作用P≥0.05）。通过限制性立方样条图探索二者间的非线性关联，结果显示整体趋势具有统计学显著性（整体检验P<0.0001），且非线性趋势同样显著（非线性检验P<0.01）。
研究结论：在本大型横断面研究中，血浆同型半胱氨酸水平升高可增加心血管疾病风险，二者之间呈非线性正相关关系。