Summary of the observed frequencies differences of co-morbid disorders between the GAIN and TGEN samples, as well as between the underlying family and bipolar singleton samples.

Key: Family refers to bipolar subjects ascertained through the collection of families for NIMH Waves 1–4. Singleton refers to bipolar subjects ascertained as singleton cases collected as part of Wave 5. Note: Significant differences in co-morbidity were not observed between bipolar subjects with irritable vs. elated mania in either sample, nor were differences observed for gender, age at interview, age at onset, age at first mania, or age at most severe mania for any comparison (i.e., irritable vs. elated mania, GAIN vs. TGEN, family vs. singleton, all p>0.10).

术语说明：家族招募组（Family）指通过收集美国国立精神卫生研究所（National Institute of Mental Health, NIMH）第1至4研究波次的家族所招募的双相情感障碍受试者；单例招募组（Singleton）指作为第5研究波次的研究组成部分招募的单例双相情感障碍受试者。
注：在两个样本中，伴易激惹躁狂与伴欣快躁狂的双相情感障碍受试者之间均未观察到共病情况的显著差异；且在所有对比组（即易激惹躁狂vs.欣快躁狂、GAIN vs. TGEN、家族招募组vs.单例招募组）中，受试者的性别、访谈时年龄、发病年龄、首次躁狂发作年龄及最严重躁狂发作年龄均无显著差异（所有p>0.10）。