The EP4 antagonist vorbipiprant and an anti-PD-1 in MSS mCRC

The aim of the study was to determine whether vorbipiprant, a prostaglandin EP4 receptor antagonist, can convert immune-resistant mCRC into a tumor responsive to anti-PD-1 inhibition Overall design: Samples from human biopsies or surgical resection of primary tumor were analyzed in order to identify potential predictors of clinical response.本研究旨在探究沃比匹兰特（vorbipiprant）——一种前列腺素EP4受体拮抗剂（prostaglandin EP4 receptor antagonist）——能否将免疫抵抗性转移性结直肠癌（mCRC）转化为对抗PD-1抑制治疗（anti-PD-1 inhibition）敏感的肿瘤。 整体实验设计：本研究对人类活检标本或原发性肿瘤手术切除标本开展分析，以识别临床应答的潜在预测因子。