Additional file 1: Table S1. of A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Human genes (105) controlling feeding behavior that were collected from scientific publications (research papers and review articles); Table S2. Human genes (336) controlling feeding behavior or body weight that were collected from OMIM; Table S3. Human genes (37) associated with syndromes that include obesity as one of the phenotypic characteristics (Bardet-Biedl, Prader-Willi, Alstrom, etc); Table S4. Data from the GWAS meta-analysis papers. Lead SNPs with genome-wide significant (p-value < 5 × 10−8) associations with BMI (164); and genes listed in GWAS meta-analysis articles and located in the regions around the 164 lead SNPs (184). Table S5. All genes from the compendium (578 genes); Table S6. The brain-specific sublist of genes (column C) that was obtained by merging two lists (presented in columns A and B); Table S7. Top twenty genes that have the maximal numbers of the first neighbors in each network (Experimental, Knowledge, Homology) and their main characteristics; Table S8. Unconnected subnetworks found within the network Homology; Table S9. Top-scoring GO terms from the chart GOTERM_BP_5 obtained with the DAVID tool for three lists of genes. The lists of genes analyzed here were obtained by extending three top-scoring clusters revealed in the protein interaction network Experimental with the MCODE tool (see Module network analysis section). Only GO terms with FDR below E-07 are presented; Table S10. Genes from the GWAS meta-analysis set that are involved in three networks (Experimental, Knowledge, Homology) and have at least one neighbor; Table S11. Genes involved in the brain-specific network of PPIs (Section A) and single (isolated) genes (Section B) that belong to the sublist brain-specific. (XLSX 188 kb)

从学术文献（包括研究论文与综述文章）中搜集得到的105个调控进食行为的人类基因，对应表S2；从在线人类孟德尔遗传数据库（OMIM, Online Mendelian Inheritance in Man）中搜集得到的336个调控进食行为或体质量的人类基因，对应表S3；37个与以肥胖为表型特征之一的综合征（如巴德-毕德综合征、普拉德-威利综合征、阿尔斯特伦综合征等）相关的人类基因，对应表S4；来自全基因组关联分析（GWAS, Genome-Wide Association Study）荟萃分析文献的数据包括：164个与体质量指数（BMI, Body Mass Index）存在全基因组显著性关联（p值<5×10^-8）的领先单核苷酸多态性位点（Lead SNPs），以及位于这164个领先单核苷酸多态性位点侧翼区域内、且被GWAS荟萃分析文献收录的184个基因，对应表S5；该汇编数据集包含的全部578个基因，对应表S6；通过合并A、B两列的基因列表得到的脑特异性基因子列表（C列），对应表S7；在实验（Experimental）、知识（Knowledge）、同源（Homology）三类网络中，一阶邻居节点数目最多的前20个基因及其核心特征，对应表S8；在同源（Homology）网络中发现的孤立子网，对应表S9；借助DAVID工具，从GOTERM_BP_5图表中筛选得到的高分基因本体（GO, Gene Ontology）生物学过程条目：本次分析的基因列表是通过MCODE工具对实验（Experimental）蛋白质相互作用网络中得到的3个最高得分聚类进行延伸得到的，仅展示错误发现率（FDR, False Discovery Rate）低于10^-7的基因本体条目，对应表S10；来自GWAS荟萃分析数据集、参与实验（Experimental）、知识（Knowledge）、同源（Homology）三类网络且至少拥有一个邻居节点的基因，对应表S11；属于脑特异性基因子列表、参与蛋白质相互作用（PPI, Protein-Protein Interaction）特异性脑网络的基因（A部分），以及该子列表中的孤立（单节点）基因（B部分），文件格式为XLSX，大小188 KB。