A Steady-state, Two-period Crossover Study to Compare the Pharmacokinetic Profile of Paroxetine After Repeated Daily Dosing of the Controlled-release Paroxetine Tablet (25 mg) With That of the Standard Immediate-release Paroxetine Tablet (20 mg) in Healthy Japanese Male Subjects

The primary purpose of this study is to compare the steady-state pharmacokinetic profile of paroxetine CR (controlled-release) at the dosage of 25mg/day using the proposed final market tablet of CR 25mg in Japan with that of standard paroxetine IR(immediate-release ) at the dosage of 20mg/day using the currently marketed tablet of IR 20mg in Japan.

本研究的核心目的为对比以下两种给药方案下的稳态药代动力学特征：一是使用日本拟最终上市的25mg帕罗西汀控释片（paroxetine CR, controlled-release），以每日25mg的剂量给药；二是使用日本当前已上市的20mg标准帕罗西汀即释片（paroxetine IR, immediate-release），以每日20mg的剂量给药。