Table_1_The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention.DOCX

Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous coronary intervention (PCI). The C-reactive protein to albumin ratio (CAR) can clarify the inflammation and nutrition status, which are highly related to clinical outcomes. This study aims to investigate the association between CAR and adverse cardiovascular events in patients with CTO undergoing PCI. For this study, 664 patients were divided into three groups based on the tertiles of CAR. The primary endpoint was all-cause mortality and the secondary endpoint was major adverse cardiovascular events (MACE). Over a median follow-up of 33.7 months, the primary endpoint occurred in 64 patients (9.6%) and the secondary endpoint occurred in 170 patients (25.6%). The patients with higher CAR represented a worse prognosis with all-cause death and cardiovascular death after the adjustment for the baseline risk factors. Adding the CAR values raised the predictive value for the incidence of the all-cause death and cardiovascular death but not MACE. The capacity of prognosis prediction was improved after the addition of the CAR value to the traditional prediction model.

炎症与营养作为核心影响因素，可对接受经皮冠状动脉介入治疗（percutaneous coronary intervention, PCI）的慢性完全性冠状动脉闭塞（chronic total coronary occlusion, CTO）患者的预后产生影响。C反应蛋白与白蛋白比值（C-reactive protein to albumin ratio, CAR）可反映机体炎症与营养状态，而该状态与临床结局密切相关。本研究旨在探讨接受PCI治疗的CTO患者中，CAR与不良心血管事件之间的关联。本研究共纳入664例患者，依据CAR的三分位间距将其分为三组。主要终点为全因死亡率，次要终点为主要不良心血管事件（major adverse cardiovascular events, MACE）。中位随访时长为33.7个月，期间64例患者（占比9.6%）达到主要终点，170例患者（占比25.6%）达到次要终点。在校正基线危险因素后，CAR水平较高的患者全因死亡与心血管死亡的预后更差。将CAR数值纳入预测模型后，可提升全因死亡与心血管死亡发生风险的预测价值，但对MACE的预测无显著改善。将CAR加入传统预测模型后，其预后预测能力得到提升。