Clinical characteristics, risk factors and complications of COVID-19 among critically ill older adults – A case control study

Background: The older population is often disproportionately and adversely affected during humanitarian emergencies, as has also been seen during the COVID-19 pandemic. Data regarding COVID-19 in older adults is usually over-generalised and does not delve into details of the clinical characteristics in them. This study was conducted to analyse clinical and laboratory characteristics, risk factors, and complications of COVID-19 between older adults who survived and those who did not.
Methods: We conducted a case-control study among older adults(age > 60 years) admitted to the Intensive Care Unit(ICU) during the COVID-19 pandemic. The non-survivors (cases) were matched with age and sex-matched survivors (control) in a ratio of 1: 3. The data regarding socio-demographics, clinical characteristics, complications, treatment, laboratory data, and outcomes were analysed.
Results: The most common signs and symptoms observed were fever (cases vs controls) (68.92 vs. 68.8%), followed by shortn..., A hospital-based case-control study was undertaken. Data was collected from the Intensive Care Unit(ICU) from December 2020 to September 2022. The sample size was calculated with a two-sided confidence level(1-α) of 95, 80% power, and with a ratio of controls to cases at 3:1. A sample size of 260 was calculated consisting of 195 controls and 65 cases. A Case was defined as a COVID-19-positive individual older than 60 years who, after being admitted or transferred to the ICU, did not survive, i.e., non-survivor. A Control was defined as a COVID-19-positive individual with age greater than 60 years who was admitted or transferred to the ICU, following which the patient recovered(survived) and was discharged alive from the hospital, i.e., survivor. Those patients who were admitted for post-COVID-19 complications or for COVID-19 unrelated medical conditions following discharge after initial treatment for COVID-19 pneumonia were excluded. The cases (non-survivors) were recruited according to..., Microsoft Excel, Word

背景：老年人群体在人道主义紧急事件中往往受不成比例的负面影响，新冠疫情（COVID-19 pandemic）期间亦是如此。现有关于老年群体新冠感染的研究数据通常过于泛化，未深入探究该群体的临床特征细节。本研究旨在对比分析存活与死亡老年新冠患者的临床及实验室特征、危险因素与并发症。
方法：本研究针对新冠疫情期间收治于重症监护病房（Intensive Care Unit，ICU）的年龄＞60岁的老年患者开展病例对照研究。以1:3的比例将非存活病例（病例组）与年龄、性别匹配的存活患者（对照组）进行配对。本研究对受试者的社会人口学特征、临床特征、并发症、治疗方案、实验室检测数据及转归进行分析。最常见的症状与体征为发热（病例组vs对照组）（68.92% vs 68.8%），其次为气短……本研究为基于医院的病例对照研究。
本研究于2020年12月至2022年9月期间从ICU收集数据。本研究的样本量按双侧置信水平（1-α）为95%、检验效能为80%、对照与病例比例为3:1进行计算，最终确定总样本量为260例，其中对照组195例，病例组65例。病例组定义为：新冠病毒检测阳性、年龄＞60岁，且在入院或转至ICU后未存活（即非存活患者）。对照组定义为：新冠病毒检测阳性、年龄＞60岁，入院或转至ICU后康复存活并从医院出院（即存活患者）。排除标准为：因新冠感染后并发症入院，或在因新冠肺炎接受初始治疗出院后因非新冠相关疾病入院的患者。病例组（非存活患者）招募依据……，数据采用Microsoft Excel、Word进行整理。