Developmental Control of non-canonical A6 Editing by REH2C in Bloodstream and Procyclic Trypanosomes

Our work aims to determine the developmental regulation of mtRNA editing in Trypanosoma brucei. We show how an RNA helicase complex (REH2C) differentially controls the editing of the A6 substrate in two lifecycle stages by modulating non-canonical edits directed by anti-initiator gRNAs.

本研究旨在阐明布氏锥虫（Trypanosoma brucei）中线粒体RNA（mitochondrial RNA, mtRNA）编辑的发育调控机制。我们揭示了RNA解旋酶复合物（REH2C）可通过调控由反起始向导RNA（anti-initiator guide RNAs, gRNAs）介导的非经典编辑事件，在两个生命周期阶段对A6底物的RNA编辑过程进行差异调控。