Data Sheet 1_Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024).pdf

AimNeonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remains inconsistent. Research topics and trends in this area remain unclear as well. This study aimed to identify key research areas, collaboration networks, and emerging trends using bibliometric analysis tools.
MethodsA comprehensive analysis was conducted on 1,165 records from the Web of Science Core Collection (WoSCC) database. Various bibliometric techniques were employed, including coauthor analysis, co-occurrence analysis, co-citation analysis, reference clustering, and topic modeling, to visualize the knowledge structure and research dynamics in the HIE field.
ResultsThe findings revealed extensive collaboration networks among authors, institutions, and countries, highlighting global efforts to address this critical neonatal condition. Recent trends identified key research areas, including TH, mild systemic hypothermia, oxidative stress, biomarkers and signaling pathways, which are essential for advancing the understanding and treatment of HIE.
ConclusionThis study provides valuable insights into the current TH for neonates with HIE. Future research should focus on optimizing treatment approaches and evaluating long-term efficacy to enhance clinical applications.

新生儿缺氧缺血性脑病（hypoxic-ischemic encephalopathy, HIE）仍是全球新生儿发病与死亡的重要诱因，亟需探索有效的治疗干预手段。当前治疗策略以亚低温治疗（therapeutic hypothermia, TH）为主，但其疗效仍存在不一致性，该领域的研究主题与发展趋势也尚不明确。本研究旨在通过文献计量分析工具，识别该领域的核心研究方向、合作网络与新兴趋势。
方法：本研究对Web of Science核心合集（Web of Science Core Collection, WoSCC）数据库中的1165条记录开展全面分析。采用多种文献计量技术，包括作者合作分析、关键词共现分析、共被引分析、文献聚类与主题建模，以可视化呈现HIE领域的知识结构与研究动态。
结果：研究结果揭示了作者、机构与国家间广泛的合作网络，彰显了全球范围内针对这一危重新生儿疾病的研究投入。本次研究识别的最新研究热点包括亚低温治疗、轻度全身性低温、氧化应激、生物标志物与信号通路，这些方向对于深化HIE的认知与治疗至关重要。
结论：本研究为当前新生儿HIE的亚低温治疗方案提供了极具价值的研究视角。未来研究应聚焦于优化治疗策略并评估长期疗效，以推动其临床应用。