Gene expression analyses of COCs treated with N-Cadherin antagonist CRS-006

N-Cadherin is a cell surface protein that is critical for cell-cell adhesion and is essential for structural integrity of tissues. In the ovary, it is expressed by granulosa cells and cumulus cells junctions throughout ovarian development. Importantly, it is also present between oocyte (egg) and surround cumulus cells, and is the only physical type of communication that is present between the egg and its surrounding cells. RNA-seq was performed on pooled COCs (n=100) treated with either CRS-066 or 0.1% DMSO vehicle during In Vitro maturation assay for comparitve analyses

N-钙粘蛋白（N-Cadherin）是一类对细胞间黏附至关重要、且对维持组织结构完整性不可或缺的细胞表面蛋白。在卵巢中，该蛋白在整个卵巢发育周期内均由颗粒细胞与卵丘细胞的连接结构表达。尤为关键的是，它同样存在于卵母细胞（卵细胞）与其周围的卵丘细胞之间，且是卵细胞与周边细胞间唯一存在的物理通信连接类型。本研究对体外成熟实验中分别经CRS-066或0.1%二甲基亚砜（DMSO）溶剂处理的合并卵冠丘复合物（COCs，n=100）进行了RNA测序（RNA-seq），以开展比较分析。