ATN 101 Data Explanation Primary Dataset in Assessment of Inflammatory Markers Associated with Neurocognitive Impairment in HIV-infected Adolescents, a Sub-study of ATN 071

Additional information dataset captured via CRF 91; comments have been redacted Study Description A sub-study of ATN 071 ("Neurocognitive Assessment in Youth Initiating HAART"), ATN 101 was an exploratory assessment comparing the results of a comprehensive neurocognitive evaluation carried out through ATN 071 to biomarkers within the plasma that correlate with immune activation, inflammation, and microbial translocation among study participants. Neurocognitive evaluations from ATN 071 were available for three years of follow-up; blood samples for ATN 101 were collected at the final ATN 071 study visit. In a subset of participants co-enrolled in ATN 061 ("Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/ritonavir (ATV/r) in Adolescents and Young Adults with CD4 + T Cells > 350 cells/mm3 Initiating HAART), biomarkers were evaluated before and after the initiation of HAART. Some biospecimens are available; for inquiries, please contact Dr. John Sleasman ([e-mail]). HIV positive youth ages 18-24 co-enrolled in ATN 071通过病例报告表（Case Report Form，CRF）91采集的附加信息数据集；注释已隐去 研究概况 ATN 101是ATN 071（"启动高效抗逆转录病毒治疗（Highly Active Antiretroviral Therapy，HAART）青少年的神经认知评估"）的子研究，属于探索性评估，旨在对比ATN 071中开展的全面神经认知评估结果与研究参与者血浆中与免疫激活、炎症及微生物易位相关的生物标志物。ATN 071的神经认知评估数据覆盖三年随访周期；ATN 101的血液样本采集于ATN 071研究的最后一次随访。在共同入组ATN 061（"CD4+T细胞＞350个/mm³且启动HAART的青少年及年轻成人中，将HAART降阶梯至阿扎那韦/利托那韦（ATV/r）后T细胞亚群的保存与扩增"）的亚组参与者中，研究人员在HAART启动前后对其生物标志物进行了评估。部分生物样本可供使用；如有咨询需求，请联系约翰·斯利斯曼博士（[e-mail]）。 研究对象：共同入组ATN 071的HIV阳性青年，年龄为18至24岁。