IADS-M sounds.

Misophonia is a condition characterized by negative affect, intolerance, and functional impairment in response to particular repetitive sounds usually made by others (e.g., chewing, sniffing, pen tapping) and associated stimuli. To date, researchers have largely studied misophonia using self-report measures. As the field is quickly expanding, assessment approaches need to advance to include more objective measures capable of differentiating those with and without misophonia. Although several studies have used sounds as experimental stimuli, few have used standardized stimuli sets with demonstrated reliability or validity. To conduct rigorous research in an effort to better understand misophonia, it is important to have an easily accessible, standardized set of acoustic stimuli for use across studies. Accordingly, in the present study, the International Affective Digitized Sounds (IADS-2), developed by Bradley and Lang (Bradley MM et al., 2007), were used to determine whether participants with misophonia responded to certain standardized sounds differently than a control group. Participants were 377 adults (132 participants with misophonia and 245 controls) recruited from an online platform to complete several questionnaires and respond to four probes (arousal, valence, similarity to personally-relevant aversive sounds, and sound avoidance) in response to normed pleasant, unpleasant, and neutral IADS-2 sounds. Findings indicated that compared to controls, participants with high misophonia symptoms rated pleasant and neutral sounds as significantly more (a) arousing and similar to trigger sounds in their everyday life, (b) unpleasant and (c) likely to be avoided in everyday life. For future scientific and clinical innovation, we include a ranked list of IADS-2 stimuli differentiating responses in those with and without misophonia, which we call the IADS-M.恐音症（Misophonia）是一种以对他人通常发出的特定重复性声音（如咀嚼、抽鼻子、敲击钢笔）及相关刺激产生负面情绪体验、耐受不良及功能受损为特征的病症。迄今为止，研究人员主要通过自我报告量表对恐音症开展研究。随着该领域的快速扩张，评估方法亟需升级，以纳入能够有效区分恐音症患者与健康对照个体的客观测量手段。尽管已有多项研究将声音作为实验刺激，但极少有研究采用经证实具备信度与效度的标准化刺激集。为开展严谨的研究以更好地理解恐音症，构建一套易于获取、可跨研究复用的标准化声学刺激集至关重要。据此，本研究采用了由Bradley与Lang（Bradley MM et al., 2007）开发的国际情感数字化声音库（International Affective Digitized Sounds, IADS-2），旨在探究恐音症参与者对特定标准化声音的反应是否与对照组存在差异。本研究从在线平台招募了377名成年人（其中132名恐音症参与者、245名健康对照个体），要求其完成多份问卷，并针对经过标准化的愉悦、不快与中性IADS-2声音完成四项评定：唤醒度、效价、与个人相关厌恶声音的相似性以及声音回避倾向。研究结果显示，与对照组相比，高恐音症症状参与者对愉悦与中性声音的评分显著更高，具体表现为：(a) 唤醒度更高且与日常生活中的触发声音更为相似；(b) 主观感受更不愉快；(c) 在日常生活中更可能被回避。为助力未来的科学与临床创新，我们整理了一份可区分恐音症患者与健康人群反应的IADS-2刺激物排名列表，将其命名为IADS-M。