Intestinal metagenomic sequencing results of A. veonii C4 after administration of T6SS positive and negative strains respectively in mice

After infecting mice with T6SS positive and negative strains of A. veronii C4, intestinal metagenomics sequencing was used to analyze the changes of intestinal microbial community composition. The objective is to elucidate the changes in intestinal microbiome composition caused by T6SS and to explain the T6SS mediated host pathogenesis in intestinal pathogens.

本研究以携带VI型分泌系统（Type VI Secretion System，T6SS）阳性与阴性的维氏气单胞菌C4（Aeromonas veronii C4）菌株感染小鼠，通过肠道宏基因组测序技术分析小鼠肠道微生物群落组成的变化。本研究旨在阐明T6SS介导的肠道微生物组组成改变，并阐释T6SS在肠道病原菌中所介导的宿主致病机制。