Functional diversity encoded in the venom gland transcriptome of C. victoriae.
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Each conotoxin superfamily is divided into groups according to cysteine framework, with the number identified in C. victoriae and a summary of biological activity associated with each group indicated.AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GABA, γ-aminobutyric acid; GPCR, G protein-coupled receptor; IC, intracranial injection; nAChR, nicotinic acetylcholine receptor; N.D., not determined; NMDA, N-Methyl-D-aspartate; sst, somatostatin.
本芋螺毒素(conotoxin)超家族依据半胱氨酸骨架划分为不同类群,文中标注了维多利亚芋螺(Conus victoriae)中已鉴定的类群数量,以及与每一类群相关的生物活性总结。AMPA:α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA);GABA:γ-氨基丁酸(GABA);GPCR:G蛋白偶联受体(GPCR);IC:颅内注射(IC);nAChR:烟碱型乙酰胆碱受体(nAChR);N.D.:未测定(N.D.);NMDA:N-甲基-D-天冬氨酸(NMDA);sst:生长抑素(sst)。
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2014-02-05



