Supplementary data 1. Significant eQTL-gene contacts identified within LGRN, Ensembl gene annotations, and LOEUF analysis results

The liver gene regulatory network (LGRN) we constructed consisted of 327,145 eQTLs and 8097 genes with 468,560 distinct spatially constrained eQTL-target gene interactions. The majority of the eQTLs (92% with single target genes, and 95% with multiple target genes) acted via cis regulatory interactions. Within the LGRN, 77% of the eQTL target genes are protein coding. Moreover, the genes that were targeted by trans-eQTLs are more likely to be intolerant to loss-of-function mutations.

我们构建的肝脏基因调控网络（LGRN）包含327145个表达数量性状基因座（eQTL）与8097个基因，共计468560种不同的空间受限eQTL-靶基因相互作用。其中绝大多数eQTL（92%仅靶向单个靶基因，95%靶向多个靶基因）通过顺式调控相互作用行使调控功能。在该LGRN中，77%的eQTL靶基因为蛋白编码基因。此外，被反式eQTL（trans-eQTL）靶向的基因更易对功能丧失突变不耐受。