Study characteristics summary.

ObjectiveTo synthesise evidence on the impact of self-isolation at home on the psychological and emotional wellbeing of adults in the general population during the COVID-19 pandemic.MethodsThis systematic review was registered on PROSPERO (CRD42022378140). We searched Medline, PsycINFO, Web of Science, Embase, and grey literature. Wellbeing included adverse mental health outcomes and adaptive wellbeing. We followed PRISMA and synthesis without meta-analysis (SWiM) guidelines. We extracted data on the impact of self-isolation on wellbeing, and factors associated with and interventions targeting wellbeing during self-isolation.ResultsThirty-six studies were included. The mode quality rating was ‘high-risk’. Depressive and anxiety symptoms were most investigated. Evidence for an impact of self-isolation on wellbeing was often inconsistent in quantitative studies, although qualitative studies consistently reported a negative impact. People with pre-existing mental and physical health needs reported increased symptoms of mental ill health during self-isolation. Studies reported modifiable stressors that have been reported in previous infectious disease contexts, such as inadequate support, poor coping strategies, inadequate and conflicting information, and highlighted the importance of regular contact from trusted healthcare professionals. Interventions targeting psychological wellbeing were rare and evaluative studies of these had high or very high risk of bias.ConclusionWhen implementing self-isolation directives, public health officials should prioritise support for individuals who have pre-existing mental or physical health needs, lack support, or who are facing significant life stressors. Focus should be directed toward interventions that address loneliness, worries, and misinformation, whilst monitoring and identifying individuals in need of additional support.研究目的：系统整合新冠疫情期间居家自我隔离对普通成年人群体心理与情绪健康的影响相关研究证据。 研究方法：本系统综述已在PROSPERO注册（注册号：CRD42022378140）。我们检索了Medline、PsycINFO、Web of Science、Embase数据库及灰色文献。本研究中的健康福祉涵盖不良心理健康结局与适应性福祉两个维度。研究严格遵循PRISMA（系统综述与元分析优先报告条目）与无元分析合成（Synthesis Without Meta-analysis, SWiM）指南开展。我们提取了自我隔离对健康福祉的影响、自我隔离期间与健康福祉相关的影响因素及针对性干预措施相关数据。 研究结果：本研究共纳入36项研究，其方法学质量评级的众数为“高偏倚风险”。研究中最常被考察的结局为抑郁与焦虑症状。定量研究中，自我隔离对健康福祉的影响证据往往存在不一致性，而定性研究则一致报告了负面效应。存在既往精神与躯体健康问题的人群，在自我隔离期间精神健康症状显著加重。研究识别出既往传染病疫情中已被报道的可干预应激源，包括支持资源不足、应对策略匮乏、信息不充分且存在冲突，并强调了来自可信医疗专业人员的定期沟通的重要性。针对心理福祉的干预措施较为稀缺，且相关评估研究存在高或极高偏倚风险。 研究结论：在推行居家自我隔离政策时，公共卫生官员应优先为存在既往精神或躯体健康问题、缺乏社会支持或正面临重大生活应激事件的人群提供支持。工作重点应聚焦于缓解孤独感、焦虑担忧与错误信息的干预措施，同时需持续监测并识别需要额外支持的个体。